FOXO4-DRI: doses reported in published research
Sources checked 2026-10-07 · 3 cited studies (0 human, 2 animal, 1 cell culture)
FOXO4-DRI is a D-retro-inverso peptide designed to interfere with the FOXO4-p53 interaction; it was described in 2017. Published dose data are from mouse and cell studies.
No human data. no human studies or registered human trials were found.
Animal studies (2)
Animal doses are listed exactly as the studies report them. They are not converted to human amounts here; doses do not translate between species by body weight.
Animal Mice (doxorubicin model), Baar et al. 2017, supplementary figure legend
- Dose as reported
- 5 mg/kg
- Route
- Intravenous
- Frequency / duration
- 3 doses, on days 1, 3 and 5
Source wording: 3× i.v. 5mg/kg FOXO4-DRI (day 1,3,5)
Baar MP, Brandt RMC, Putavet DA et al.. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell 2017. PubMed PMID 28340339 ↗ · full text PMC5556182 ↗
Animal Naturally aged male mice (20-24 months)
- Dose as reported
- 5 mg/kg
- Route
- Intraperitoneal
- Frequency / duration
- Every other day for 3 administrations
Source wording: the aged mice were intraperitoneally injected with FOXO4-DRI (5 mg/kg) in PBS or PBS alone every other day for three administrations
Zhang C, Xie Y, Chen H et al.. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY) 2020. PubMed PMID 31959736 ↗ · full text PMC7053614 ↗
Cell-culture studies (1)
Cell culture (in vitro) Human IMR90 fibroblasts (senescent and control), Baar et al. 2017
- Dose as reported
- 25 µM
- Route
- Added to cell culture
- Frequency / duration
- Imaged for 6 days after addition
Source wording: 25μM FOXO4-DRI. After 8h the cells were processed for real-time imaging for 6 days in total.
Baar MP, Brandt RMC, Putavet DA et al.. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell 2017. PubMed PMID 28340339 ↗ · full text PMC5556182 ↗
Half-life
No half-life value was found in the sources reviewed for this page.
About this page
- Every figure above is copied from the cited source; the source wording is shown with each entry. Where a source does not state something, the page says so.
- Only abstracts, open-access full texts, registry records and FDA labels were used, so details found only in a paywalled full text may be missing.
- This page does not convert doses between species or into other measures, and gives no preparation or handling information.
See also: FOXO4-DRI research profile · lab-tested lots (COA lookup) · all compounds in this section.